Regulation of monoubiquitinated PCNA by DUB autocleavage
نویسندگان
چکیده
منابع مشابه
Regulation of Human Separase by Securin Binding and Autocleavage
BACKGROUND Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion. Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates. In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, w...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2006
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb1378